<![CDATA[Papa Heme's Educational Portal: Learning Tools]]>https://aarongoodman.substack.com/s/learning-toolshttps://substackcdn.com/image/fetch/$s_!1he1!,w_256,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Febe28d0c-02bd-488f-be82-5beaf439c60a_1280x1280.pngPapa Heme's Educational Portal: Learning Toolshttps://aarongoodman.substack.com/s/learning-toolsSubstackTue, 21 Apr 2026 03:17:34 GMT<![CDATA[D-dimer and fibrinogen]]>https://aarongoodman.substack.com/p/d-dimer-and-fibrinogenhttps://aarongoodman.substack.com/p/d-dimer-and-fibrinogenTue, 28 Mar 2023 01:12:58 GMTD-dimer Mathematics!

Fibrinogen = 3 domains = central E + 2D

Thrombin cleaves fibrino-peptides (A and B) in E = Fibrin monomers

With fibrin-peptides A and B gone the monomers can polympermize

Fibrin monomers polymerize = Fibrin polymers

FXIIIa crosslinks D in polymers = (D-D)E-(DD)E... = cross linked fibrin and clot stabilized!

!

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]]><![CDATA[Learn Cabot Rings!]]>https://aarongoodman.substack.com/p/learn-cabot-ringshttps://aarongoodman.substack.com/p/learn-cabot-ringsMon, 27 Mar 2023 20:15:27 GMTHere’s what you need to know:

  • Found rarely in RBCs

  • Thin

  • Red-violet staining

  • Threadlike strands

  • Figure-8 shape or ring

Represent microtubule remnants of mitotic spindle!

Seen in:

  • Megaloblastic anemias

  • MDS

  • Dyserythropoiesis

JCarr BioMed

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]]><![CDATA[Lymphomagenesis Made Easy!]]>https://aarongoodman.substack.com/p/lymphomagenesis-made-easyhttps://aarongoodman.substack.com/p/lymphomagenesis-made-easyMon, 27 Mar 2023 17:01:11 GMT

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]]><![CDATA[DOACs and Renal Impairment! ]]>https://aarongoodman.substack.com/p/doacs-and-renal-impairmenthttps://aarongoodman.substack.com/p/doacs-and-renal-impairmentSun, 26 Mar 2023 17:18:39 GMTHere’s what you need to know

% Renal Excretion:

Dabigatran: 80%

Rivaroxaban: 66%

Edoxaban: 40%

Apixaban: 25%

Betrixaban: 11%

To remember the order from worst to best to give for patients with renal impairment: DR. Ed ABe

Papa Heme's Educational Portal is a reader-supported publication. Get access to all of my learning tools, board reviews, and lectures by…

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]]><![CDATA[Learn Hematopoiesis during human development!]]>https://aarongoodman.substack.com/p/learn-hematopoiesis-during-humanhttps://aarongoodman.substack.com/p/learn-hematopoiesis-during-humanSat, 25 Mar 2023 14:05:48 GMTHere’s the roadmap I use:

Fetus:

  • 0-2 months = yolk sac

  • 2-7 months = liver/spleen

  • 5-9 months = bone marrow

Infants:

  • All bones!

Adults:

  • Vertebrae, ribs, skull, sternum, sacrum, pelvis, proximal femurs

[Image from Wikipedia.org]

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]]><![CDATA[Learn Mature B-cell Leukemia flow patterns by CD5/CD10!]]>https://aarongoodman.substack.com/p/learn-mature-b-cell-leukemia-flowhttps://aarongoodman.substack.com/p/learn-mature-b-cell-leukemia-flowSat, 25 Mar 2023 13:32:18 GMT CD5+/CD10-:

  • CLL = CD23+

  • Leukemic mantle cell = CD23-, FMC7+,SOX11-

CD5-/CD10-:

  • Hairy cell leukemia = CD11c+, CD123+, BRAF+

  • HCLv = CD11c+, CD123-, BRAF-

  • SMZL = HCV, del7q31, MYD88 mutated (subset)

  • B-PLL = CD5+/-, TP53 mutated

  • LPL = MYD88 mutated

CD5-/CD10+:

  • Leukemic follicular

  • Leukemic Burkitt

Atlas of Hematological Cytology

Papa Heme's Educational Portal i…

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]]><![CDATA[Hydroxyurea Sickle Cell Anemia!]]>https://aarongoodman.substack.com/p/hydroxyurea-sickle-cell-anemiahttps://aarongoodman.substack.com/p/hydroxyurea-sickle-cell-anemiaFri, 24 Mar 2023 20:50:08 GMT

Mechanism

⬆️ HbF

⬇️ WBC

⬇️ RBC adherence to endothelium

⬆️ RBC hydration = ⬇️ HbS polymerization

⬆️ Nitric oxide

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]]><![CDATA[Learn viruses + hematologic malignancies! ]]>https://aarongoodman.substack.com/p/learn-viruses-hematologic-malignancieshttps://aarongoodman.substack.com/p/learn-viruses-hematologic-malignanciesThu, 23 Mar 2023 13:26:17 GMT

EBV =

  • Burkitt lymphoma (endemic)

  • Primary CNS lymphoma (+HIV)

  • Hodgkin lymphoma

  • Angioimmunoblastic T-cell lymphoma

  • Extranodal NK/T-cell lymphoma

  • Aggressive NK leukemia

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]]><![CDATA[Anticoagulant Mechanism Name Jewels]]>https://aarongoodman.substack.com/p/anticoagulant-mechanism-name-jewelshttps://aarongoodman.substack.com/p/anticoagulant-mechanism-name-jewelsWed, 22 Mar 2023 23:17:00 GMTDrugs target Xa = Xa in name

  • ApiXaban

  • BetriXaban

  • EdoXaban

  • RivaroXaban

Drugs target BOTH Xa+thrombin = PARIN (pair) in name

  • HeParin

  • EnoXaParin

  • DalteParin

Drugs target only IIa = B (2nd letter)

  • ArgatroBan

  • Bivalrudin

  • DaBigatran

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]]><![CDATA[Slide of the Day (3/23/23)]]>https://aarongoodman.substack.com/p/slide-of-the-day-32323https://aarongoodman.substack.com/p/slide-of-the-day-32323Wed, 22 Mar 2023 23:16:12 GMTLook into my eyes and tell me the following...

1. Name of this cell and diagnosis (med student level)

Papa Heme's Educational Portal is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

2. Immunophenotype (path resident/heme fellow level)

3. Chromosome locus abnormality (hematologist le…

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]]><![CDATA[Pathology Images to Know for USMLE Step 1]]>https://aarongoodman.substack.com/p/pathology-images-to-know-for-usmlehttps://aarongoodman.substack.com/p/pathology-images-to-know-for-usmleWed, 08 Mar 2023 14:42:52 GMTPathologists, please add more if I am missing any key images in the comments!

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]]><![CDATA[Blood Smear of the Day (3/8/23)]]>https://aarongoodman.substack.com/p/blood-smear-of-the-dayhttps://aarongoodman.substack.com/p/blood-smear-of-the-dayWed, 08 Mar 2023 14:26:10 GMTInternal Medicine Board Review!

A 70-year-old patient presents with

WBC 35,000

Hb 7

Put 150

LDH 550

Bili 2.5

Coombs positive

Blood smear below.

What is the diagnosis?

[Lovely image from ASH Image Bank]

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]]><![CDATA[Blood Smear of the Day (3/3/23)]]>https://aarongoodman.substack.com/p/blood-smear-of-the-day-3323https://aarongoodman.substack.com/p/blood-smear-of-the-day-3323Fri, 03 Mar 2023 20:12:18 GMTA 75-year-old with new onset microcytic hypochromic anemia.  Diagnosis?

Post your answer in the comments!

*Image from Radcliff Department of Medicine Oxford University

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]]><![CDATA[Papa Heme's World Famous Hematology Cheat Sheets for Medical Students]]>https://aarongoodman.substack.com/p/papa-hemes-world-famous-hematologyhttps://aarongoodman.substack.com/p/papa-hemes-world-famous-hematologyWed, 22 Feb 2023 19:28:47 GMT

Papa Heme's Hematology Cheat Sheets For Medical Students
86.7KB ∙ PDF file
Download
If you know this table you will ace the malignant hematology sections of your board exams!
Download

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]]><![CDATA[Papa Heme's Cheat Sheets - AML Edition!]]>https://aarongoodman.substack.com/p/papa-hemes-cheat-sheets-aml-editionhttps://aarongoodman.substack.com/p/papa-hemes-cheat-sheets-aml-editionMon, 20 Feb 2023 22:30:13 GMT

AML

Pathogenesis:

  • Block in differentiation (transcription factor)

  • Proliferative mutation (tyrosine kinase)

Bone Marrow

  • Hypercellular

  • Full of blasts >20%(no maturation)

Age

  • Increases with age

  • Predominately disease of elderly

CBC

  • Leukocytosis

  • Anemia

  • Thrombocytopenia

  • Pancytopenia

  • Can have low, normal, or elevated WBC!!!

Disease Tempo:

  • Fast

Lymph node involvement:

  • Very very …

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